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. 2019 Apr;95(4):337–348. doi: 10.1124/mol.118.114348

Fig. 7.

Fig. 7.

Compound 51164 recovers LTP induction in slices from 6-month-old 5xFAD mice. (A and C) LTP is not altered in hippocampal slices from 2-month-old 5xFAD mice. Incubation of slices with 100 nM of compound 51164 does not influence LTP induction in slices from 2-month-old WT and 5xFAD mice (3–5 mice per group). Two-way ANOVA, F1,14 = 0.64, P = 0.44 [WT (n = 4 slices); WT (compound 51164) (n = 5); 5xFAD (n = 3); 5xFAD (compound 51164) (n = 6)]. (B and D) LTP is impaired in hippocampal slices from 6-month-old 5xFAD mice. Incubation of 5xFAD slices from 6-month-old 5xFAD mice with 100 nM of compound 51164 recovers LTP induction. Two-way ANOVA following Tukey’s post hoc test, F1,31 = 6.31, P = 0.02. In 6-month-old WT slices compound 51164 does not change LTP (P = 0.99) [WT (n = 8); WT (compound 51164) (n = 6); 5xFAD (n = 12); 5xFAD (compound 51164) (n = 9)]. *P < 0.05; **P < 0.01].