TABLE 1.

List of TRPC6 agonists from the Clarivate Analytics Integrity database

Integrity ID	IUPAC Name	Structural Formula	Molecular Mechanism	Therapeutic Group
HYP-1	2,4-Bis(3-methylbutyryl)phloroglucinol 2,4-bis(3-methylbutyryl)-1,3,5-trihydroxybenzene		1) TRPC6 agonists; 2) leukotriene CysLT1 (LTD4) antagonists; 3) antagonists free fatty acid receptor 1 (FFAR1; PR40); 4) agonists signal transduction modulators; 5) prostanoid thromboxane receptors antagonists; and 6) leukotriene antagonists	1) Antiallergy/antiasthmatic drugs; 2) antiviral; and 3) agents for type 2 diabetes
HYP-5	1,1′-(2,4,6-Trihydroxybenzene-1,3-diyl)bis(4-methylpentan-1-one)		1) TRPC6 Agonists	1) Treatment of cognition disorders
HYP-9	1,1′-(2,4,6-Trihydroxybenzene-1,3-diyl)dihexan-1-one		1) TRPC6 Agonists	1) Treatment of cognition disorders
830288	[4-(5-Chloro-2-methylphenyl)piperazin-1-yl](3-fluorophenyl)methanone		1) TRPC6 Agonists	1) Psychiatric disorders (not specified); and 2) treatment of neurodegenerative diseases
871099	N-(2-Chlorophenyl)-2-[4-(2,3-dimethylphenyl)piperazin-1-yl]acetamide trifluoroacetate		1) TRPC6 agonists; and 2) TRPC3 agonists	1) Psychiatric disorders (not specified); and 2) treatment of neurodegenerative diseases
880395	2-[4-(2,3-Dimethylphenyl)piperazin- 1-yl]-N-(2-fluorophenyl)acetamide trifluoroacetate		1) TRPC6 agonists; and 2) TRPC3 agonists	1) Psychiatric disorders (not specified); and 2) treatment of neurodegenerative diseases

ID, identification; IUPAC, International Union of Pure and Applied Chemistry.