Table 3.
Clinicopathological characteristics of patients with cholangiocarcinoma as the lone primary and those with cholangiocarcinoma as the first of two or more primaries
| One primary, n=11,172 | First of two or more primaries, n=323 | P-value | |
|---|---|---|---|
|
| |||
| Age at diagnosis, years | 64.96±12.64 | 64.73±12.25 | 0.743 |
| Sex, n (%) | 0.048 | ||
| Male | 5,769 (51.64) | 185 (57.28) | |
| Female | 5,403 (48.36) | 138 (42.72) | |
| Race, n (%) | 0.546 | ||
| White | 8,751 (78.33) | 262 (81.11) | |
| Black | 901 (8.06) | 20 (6.19) | |
| Other | 1,510 (13.52) | 41 (12.69) | |
| Unknown | 10 (0.09) | 0 (0) | |
| Marital status, n (%) | 0.87 | ||
| Married | 6,651 (59.53) | 197 (60.99) | |
| Unmarried | 4,132 (36.99) | 115 (35.6) | |
| Unknown | 389 (3.48) | 11 (3.41) | |
| Location, n (%) | 0.278 | ||
| Intrahepatic | 7,775 (69.59) | 222 (68.73) | |
| Perihilar | 2,362 (21.14) | 79 (24.46) | |
| Distal | 516 (4.62) | 12 (3.72) | |
| Other | 519 (4.65) | 10 (3.1) | |
| Grade, n (%) | <0.001 | ||
| Grade I, well differentiated | 605 (5.42) | 29 (8.98) | |
| Grade II, moderately differentiated | 2,322 (20.78) | 99 (30.65) | |
| Grade III, poorly differentiated | 2,153 (19.27) | 59 (18.27) | |
| Grade IV, undifferentiated | 85 (0.76) | 1 (0.31) | |
| Unknown | 6,007 (53.77) | 135 (41.8) | |
| SEER histological stage, n (%) | <0.001 | ||
| Localized | 2,320 (20.77) | 105 (32.51) | |
| Regional | 3,432 (30.72) | 107 (33.13) | |
| Distant | 4,422 (39.58) | 75 (23.22) | |
| Unknown | 998 (8.93) | 36 (11.15) | |
| AJCC sixth stage, n (%) | <0.001 | ||
| I | 1,137 (10.18) | 50 (15.48) | |
| II | 485 (4.34) | 31 (9.6) | |
| III | 2,098 (18.78) | 58 (17.96) | |
| IV | 3,280 (29.36) | 49 (15.17) | |
| Unknown | 4,172 (37.34) | 135 (41.8) | |
| Tumor size, n (%) | <0.001 | ||
| <5 cm | 2,009 (17.98) | 90 (27.86) | |
| 5–10 cm | 1,916 (17.15) | 52 (16.56) | |
| >10 cm | 750 (6.71) | 13 (3.99) | |
| Unknown | 6,497 (58.15) | 168 (52.01) | |
| Surgery for first primary site, n (%) | <0.001 | ||
| Yes | 2,502 (22.40) | 157 (48.61) | |
| No | 7,122 (63.75) | 120 (37.15) | |
| Unknown | 1,548 (13.86) | 46 (14.24) | |
| Latency | – | 23.73±40.83 | |
| Number of primaries, n (%) | |||
| 2 primaries | – | 300 (92.88) | |
| 3 primaries | – | 18 (5.57) | |
| 4 primaries | – | 4 (1.24) | |
| 5 primaries | – | 1 (0.31) | |
| SEER histological stage of SPM, n (%) | |||
| Distant | – | 62 (19.2) | |
| No distant | – | 184 (56.97) | |
| Unknown | – | 77 (23.84) | |
Abbreviations: AJCC, American Joint Committee on Cancer; SEER, Surveillance, Epidemiology and End Results; SPM, second primary malignancy.