Table 4.

Clinicopathological characteristics of patients with cholangiocarcinoma as the only primary and patients with cholangiocarcinoma as the first of two or more primaries (matched number of cases)

Parameters	One primary, n=323	First of two or more primaries, n=323	P-value
Age at diagnosis, years (mean ± SD)	64.76±12.47	64.73±12.25	0.972
Sex, n (%)			0.027
Male	156 (48.3)	185 (57.28)
Female	167 (51.7)	138 (42.72)
Race, n (%)			0.114
White	241 (74.61)	262 (81.11)
Black	31 (9.6)	20 (6.19)
Other	51 (15.79)	41 (12.69)
Marital status, n (%)			0.697
Married	188 (58.20)	197 (60.99)
Unmarried	121 (37.46)	115 (35.6)
Unknown	14 (4.33)	11 (3.41)
Location, n (%)			0.440
Intrahepatic	236 (73.07)	222 (68.73)
Perihilar	62 (19.20)	79 (24.46)
Distal	13 (4.02)	12 (3.72)
Others	12 (3.72)	10 (3.1)
Grade, n (%)			0.001
Grade I, well differentiated	17 (5.26)	29 (8.98)
Grade II, moderately differentiated	65 (20.12)	99 (30.65)
Grade III, poorly differentiated	58 (17.96)	59 (18.27)
Grade IV, undifferentiated	3 (0.93)	1 (0.31)
Unknown	180 (55.73)	135 (41.8)
SEER histological stage, n (%)			<0.001
Localized	63 (19.50)	105 (32.51)
Regional	122 (37.77)	107 (33.13)
Distant	118 (36.53)	75 (23.22)
Unknown	20 (6.19)	36 (11.15)
AJCC sixth stage, n (%)			<0.001
I	32 (9.91)	50 (15.48)
II	6 (1.86)	31 (9.6)
III	70 (21.67)	58 (17.96)
IV	91 (28.17)	49 (15.17)
Unknown	124 (38.39)	135 (41.8)
Tumor size, n (%)			0.007
<5 cm	54 (16.72)	90 (27.86)
5–10 cm	61 (18.89)	52 (16.56)
>10 cm	19 (5.88)	13 (3.99)
Unknown	189 (58.51)	168 (52.01)
Surgery for first primary site, n (%)			<0.001
Yes	66 (20.43)	157 (48.61)
No	213 (65.94)	120 (37.15)
Unknown	44 (13.62)	46 (14.24)

Abbreviations: AJCC, American Joint Committee on Cancer; SEER, Surveillance, Epidemiology and End Results.