Table 5.
Multivariable logistic regression for the presence of multiple primary malignancies after cholangiocarcinoma diagnosis
| Parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
|
| ||||
| Age at diagnosis, years | ||||
| ≤29 | 1 [Reference] | |||
| 30–59 | 0.621 (0.192–2.01) | 0.427 | / | / |
| ≥60 | 0.654 (0.204–2.095) | 0.475 | / | / |
| Sex | ||||
| Male | 1 [Reference] | |||
| Female | 0.796 (0.637–0.996) | 0.046 | / | / |
| Race | ||||
| White | 1 [Reference] | |||
| Black | 0.741 (0.468–1.174) | 0.202 | / | / |
| Other | 0.907 (0.650–1.266) | 0.566 | / | / |
| Unknown | 0 | 0.999 | / | / |
| Marital status | ||||
| Married | 1 [Reference] | |||
| Unmarried | 0.94 (0.744–1.186) | 0.601 | / | / |
| Unknown | 0.955 (0.516–1.767) | 0.883 | / | / |
| Location | ||||
| Intrahepatic | 1 [Reference] | |||
| Perihilar | 1.171 (0.902–1.521) | 0.235 | / | / |
| Distal | 0.814 (0.453–1.466) | 0.494 | / | / |
| Other | 0.675 (0.356–1.280) | 0.228 | / | / |
| Grade | ||||
| Grade I, well differentiated | 1 [Reference] | |||
| Grade II, moderately differentiated | 0.889 (0.582–1.358) | 0.588 | / | / |
| Grade III, poorly differentiated | 0.572 (0.363–0.9) | 0.016 | / | / |
| Grade IV, undifferentiated | 0.245 (0.033–1.825) | 0.17 | / | / |
| Unknown | 0.469 (0.311–0.706) | <0.001 | / | / |
| SEER histological stage | ||||
| Localized | 1 [Reference] | |||
| Regional | 0.689 (0.524–0.906) | 0.008 | / | / |
| Distant | 0.375 (0.277–0.506) | <0.001 | / | / |
| Unknown | 0.797 (0.542–1.172) | 0.249 | / | / |
| AJCC sixth stage | ||||
| I | 1 [Reference] | |||
| II | 1.453 (0.917–2.304) | 0.111 | / | / |
| III | 0.629 (0.428–0.924) | 0.018 | / | / |
| IV | 0.34 (0.228–0.507) | <0.001 | / | / |
| Unknown | 0.736 (0.528–1.025) | 0.069 | / | / |
| Tumor size | ||||
| <5 cm | 1 [Reference] | |||
| 5–10 cm | 0.606 (0.428–0.857) | 0.005 | / | / |
| >10 cm | 0.387 (0.215–0.696) | 0.002 | / | / |
| Unknown | 0.577 (0.445–0.749) | <0.001 | / | / |
| Surgery for first primary site | ||||
| Yes | 1 [Reference] | 1 [Reference] | ||
| No | 0.269 (0.211–0.342) | <0.001 | 0.269 (0.211–0.342) | <0.001 |
| Unknown | 0.474 (0.339–0.662) | <0.001 | 0.474 (0.339–0.662) | <0.001 |
Abbreviations: AJCC, American Joint Committee on Cancer; SEER, Surveillance, Epidemiology and End Results.