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. 2019 Feb 27;13:77. doi: 10.3389/fnins.2019.00077

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Copyright © 2019 Alvarado, Fuentes-Santamaría, Gabaldón-Ull and Juiz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Line graphs illustrating auditory thresholds and threshold shifts at the different frequencies evaluated in NE and E rats at 3, 6, 12, and 18 months. In both NE3 and E3 animals, previous any noise exposure, the mean values of the auditory thresholds were similar (A). At 6 months, the auditory thresholds (B) and the threshold shifts (E) in E6 rats were significantly higher than those found in the NE6 rats. Although, auditory thresholds (C) and threshold shifts (F) were elevated in both NE12 and E12 groups, these values were still statistically significantly higher in the E12 rats when compared to NE12 animals. At 18 months of age, no significant differences were detected between noise exposed and non-exposed rats (D,G). ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.