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. 2019 Feb 27;13:77. doi: 10.3389/fnins.2019.00077

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Copyright © 2019 Alvarado, Fuentes-Santamaría, Gabaldón-Ull and Juiz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bar graphs illustrating wave amplitude ratios in noise-exposed animals at 6, 12, and 18 months of age relative to the control condition. In 6-month-old exposed animals, (A–C), wave amplitude ratios for all waves and at all frequencies were significantly smaller when compared to the non-exposed rats. At 12 months, while ratios decreased in both NE and E groups, in E animals the mean values were still significantly reduced at the highest frequencies for waves I (D) and II (E), but not for wave IV (F). In the oldest animals (G–I), the mean values remained reduced in both groups and significant differences were observed only in wave II (H) at 8, 16, and 32 kHz. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.