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. Author manuscript; available in PMC: 2019 Mar 6.
Published in final edited form as: J Immunol Sci. 2018 Jun 13;2(3):59–68. doi: 10.29245/2578-3009/2018/3.1143

Table 1:

Interaction between HDAC6 and ERK pathway components

ERK pathway Components Interaction Function References
EGFR HDAC6 attenuates EGFR endocytic trafficking and degradation via deacetylating microtubules Inhibition HDAC6 enhances EGFR degradation Deribe et al., 2009; Gao et al., 2010
EGFR EGFR phosphorylates HDAC6 Tyr570 EGFR phosphorylates HDAC6 and reduces HDAC6 deacetylase activity Deribe et al., 2009
KRAS HDAC6 deacetylates KRAS Inhibition of HDAC6 weakens cell transformation by mutational KRAS Yang et al., 2013
ERK1 ERK1 phosphorylates HDAC6 Thr1031 and Ser1035 Phosphorylation of HDAC6 Ser1035 is critical for its deacetylase activity Williams et al., 2013
ERK1 HDAC6 deacetylates ERK1 Lys72 Acetylation of ERK1 Lys72 impairs its kinase activity Wu et al.,2018