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. 2019 Feb 27;11(4):1204–1225. doi: 10.18632/aging.101829

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Copyright © 2019 Chai et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Interaction among m⁶A RNA methylation regulators and functional annotation of gliomas in RM1/2 subgroups. (A) The m⁶A modification-related interactions among the 13 m⁶A RNA methylation regulators. (B) Spearman correlation analysis of the 13 m⁶A modification regulators. (C) Principal component analysis of the total RNA expression profile in the CGGA dataset. Gliomas in the RM2 subgroup are marked with red. (D–E) Functional annotation of the genes with higher expression in the RM2 subgroup (red bar chart) or RM1 subgroup (green bar chart) using GO terms of biological processes (D) and KEGG pathway (E). (F) GSEA revealed that genes with higher expression in RM2 subgroup were enriched for hallmarks of malignant tumors.