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. 2019 Feb 21;11(4):1089–1109. doi: 10.18632/aging.101766

Figure 9.

Figure 9

AntgoMALAT1 protects mice against atherosclerosis. (A, B) The expression of MALAT1 was determined by qRT-PCR in plasma and aortic tissue from ApoE−/− +RCD and ApoE−/− +HFD mice which were injected with antagoMALAT1 or antagoNC, n=5. **P<0.01, compared with antagoNC group; ##P<0.01, compared with ApoE−/− +RCD group. (C) Western blot result of MAPK1, phosphorylated mTOR, mTOR and autophagy related protein ATG1 and LC3-II in ApoE−/− +RCD group. **P<0.01, compared with antagoNC group. (D) Western blot result of MAPK1, phosphorylated mTOR, mTOR and autophagy related protein ATG1 and LC3-II in ApoE−/− +HFD group. **P<0.01, compared with antagoNC group. (E) QRT-PCR results of VCAM-1/ICAM-1 expression with the different treatment in ApoE−/− +RCD and ApoE−/− +HFD groups. **P<0.01, compared with antagoNC group; ##P<0.01, compared with ApoE−/− +RCD group.