Table 1.

Databases and Web servers for cancer drug resistance

Databases	Data deposited	Potential applications	Year	Web site	Reference
CancerDR	Pharmacological profiling information of 148 anticancer drugs across 952 cancer cell lines	Identify genetic mutations in the drug targets and the associated residues responsible for drug resistance	2013	http://crdd.osdd.net/raghava/cancerdr/	[51]
HerceptinR	2500 Herceptin assays performed to test efficacy of Herceptin on various breast cell lines (∼30 unique cell lines) with and without supplementary drugs (∼100 unique drugs)	Assist to design Hercepting biomarkers to test whether Herceptin will work for a specific patient and examine whether Herceptin with supplementary drug can be used to treat this patient	2014	http://crdd.osdd.net/raghava/herceptinr/	[52]
MACE	Individual GI50 data of chemicals against NCI60 cell lines with DNA microarray data	Analyze mutation- or lineage-specific chemical response and expression signatures	2015	http://mace.sookmyung.ac.kr/	[53]
mutLBSgeneDB	Over 2300 genes with ∼12 000 somatic mutations at ∼10 000 ligand-binding sites across 16 cancer types; 744 drug-targetable genes	Search gene summary, mutated information, protein structure-related information, differential gene expression and gene–gene network, phenotype information, pharmacological information and conservation information	2017	http://zhaobioinfo.org/mutLBSgeneDB	[54]
GEAR	1781 associations between drugs and genomic elements (e.g. genes, miRNAs and SNPs)	Predict genomic elements that are responsible for drug resistance	2017	http://gear.comp-sysbio.org/	[55]