Figure 4.

Effects of MPH on 19 single neuron response metrics. A, Visual response metrics for visually-selective neurons as a function of drug dose. Refer to Materials and Methods for the meaning of each metric. The x-axis depicts MPH drug dose using arbitrary units (a.u.), from the smallest dose to the biggest for each monkey. These are 0.43, 0.86, 1.08, 1.29, or 1.72 mg/kg for monkey “F,” and 0.33, 0.67, 0.83, 1.00, or 1.33 mg/kg for monkey “JL.” The y-axis is relative to the particular metric being plotted. Blue and green lines are for monkey “F” and monkey “JL,” respectively. The top-leftmost subplot includes the size of single neurons samples included for the computation of all the visual metrics. The red error bars correspond to the best-dose of MPH according to behavioral performance. The colored numbers to the right of each line represent the p values for the ANOVA test ran for each metric, uncorrected (top), and corrected for multiple comparisons (bottom). B, Same as in A but for the attentional response metrics of attention-selective neurons. C, Same as in A but for the saccadic response metrics of saccade-selective neurons. All error bars represent SEM.