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Freshly translated α-tubulin contains a C-terminal tyrosine residue. After forming a dimer with β-tubulin, it assembles into microtubules. Vasohibin-SVBP complex removes C-terminal tyrosine residues from tubulin polymers and thus generates detyrosinated microtubules. When these microtubules disassemble, detyrosinated tubulin can be re-tyrosinated by tyrosine-tubulin ligase.
