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The GI50 (μM) values of different SIRT2 inhibitors on the anchorage-independent growth of HCT116 cells with and without SIRT2 overexpression.
| AGK2 | SirReal2 | Tenovin-6 | TM | |
|---|---|---|---|---|
| Control | 24.1 | 55.8 | 2.1 | 13.5 |
| SIRT2 expression | 27.6 | 58.1 | 2.3 | 24.2 |
| Fold Change[a] | 1.2 | 1 | 1.1 | 1.8 |
(GI50 for SIRT2 expression) / (GI50 for Control)
Results were obtained from all individual samples from at least three replicates, standard deviation are presented in supplemental information.
