Fig 4. Signature probability mean absolute errors on synthetic data.

Shown are mean absolute errors per method and per signature (n = 20) for estimated signature probabilities compared to reference probabilities. The experiment was repeated with full mutation counts and with 1% SNVs & 10% SVs. Data is represented as Tufte-like boxplots with the following elements: points (medians), gaps (first to third quartiles), whiskers (extend to the most extreme value no further than 1.5X the inter-quartile range from the gap edge), dashes (outliers). NMF: applied to raw counts, NMF-norm: applied to normalized counts.