Figure 3. Effect of cancer treatments on KLRG1 and other checkpoint receptor expression in human cancer pre- and post-treatment tumor biopsy public domain datasets.

(A–D) Illustrative examples of checkpoint receptor changes compared to baseline pretreatment (fold-ratio = 1.0) after (A) immunotherapy, (B) chemotherapy, and (C, D). (E) Numerically increased post-treatment KLRG1 expression changes in 20/21 datasets organized by treatment modality. Abbreviations: xRT, radiation therapy; Endo, endocrine therapy; Chemo, chemotherapy; Immuno, immunotherapy. P-values: blank = not-significant; ^* < 0.05, ^**<0.01, ^***<0.001, ^****<0.0001.