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. 2019 Feb 15;10(14):1458–1472. doi: 10.18632/oncotarget.26680

Figure 6. Role of CD4+ and CD8+ T cells in tumor protection.

Figure 6

BALB/c mice were challenged with CT26 cells and were vaccinated with Ad5-MelARV after two days (d.2 p.c.) (dark lines). T cell depletion antibodies were administered on days 5, 8 and 11. Unvaccinated mice served as negative controls (light grey lines) (n = 7). Each line represents a single mouse in the course of the experiment. (A) A control group of vaccinated mice was injected i.p. with rat IgG2b isotype control (n = 7). (B) Depletion of CD4+ T cells by i.p. injection of anti-mouse CD4 antibodies (n = 7). (C) Depletion of CD8+ T cells by i.p. injection of anti-mouse CD8 antibodies (n = 7).