Table 1.
Characteristics of hydroxychloroquine incident users by time period of initial prescription (2007–2016)
| Characteristics | 2007–2008 (n = 3793) | 2009–2010 (n = 3388) | 2011–2012 (n = 3600) | 2013–2014 (n = 3120) | 2015–2016 (n = 3896) | All (n = 17,797) |
|---|---|---|---|---|---|---|
| Sex (% female) | 3044 (80.3) | 2744 (81.0) | 2940 (81.7) | 2570 (82.4) | 3214 (82.5) | 14,512 (81.5) |
| Age, mean (SD) | 53.3 (15.0) | 53.5 (15.1) | 53.8 (15.7) | 53.1 (15.7) | 52.5 (15.8) | 53.2 (15.5) |
| CKD (≥ stage 3) | 120 (3.2) | 151 (4.5) | 206 (5.7) | 194 (6.2) | 195 (5.0) | 866 (4.9) |
| BMI (kg/m2), mean (SD) | 28.4 (6.7) | 28.6 (6.7) | 28.3 (6.7) | 28.4 (6.7) | 28.3 (6.6) | 28.4 (6.7) |
| BMI Category | ||||||
| Underweight (< 18.5) | 46(1.2) | 63 (1.9) | 51 (1.4) | 45 (1.5) | 43 (1.1) | 248 (1.4) |
| Normal (18.5–24.9) | 1280 (33.8) | 1062 (31.4) | 1226 (34.1) | 1068 (34.3) | 1289 (33.2) | 5925 (33.4) |
| Overweight (25–29.9) | 1197 (31.6) | 1097 (32.4) | 1134 (31.5) | 968 (31.1) | 1279 (32.9) | 5675 (31.9) |
| Obese (≥ 30) | 1261 (33.3) | 1163 (34.36) | 1186 (33.0) | 1033 (33.2) | 1274 (32.8) | 5917 (33.3) |
| Prescriber specialty (%) | ||||||
| Rheumatologist | 2449 (64.6) | 2394 (70.7) | 2513 (69.8) | 2164 (69.4) | 2785 (71.5) | 12,305 (69.1) |
| Primary care | 976 (25.7) | 638 (18.8) | 638 (18.8) | 505 (16.2) | 541 (13.9) | 3255 (18.3) |
| Dermatologist | 242 (6.4) | 253 (7.5) | 340 (9.4) | 340 (9.4) | 340 (9.4) | 1517 (8.5) |
| Other | 126 (3.3) | 103 (3.0) | 152 (4.2) | 135 (4.3) | 204 (5.2) | 720 (4.1) |
| Indication (%) | ||||||
| Rheumatoid arthritis | 1669 (44.0) | 1577 (46.6) | 1705 (47.4) | 1431 (45.9) | 1853 (47.6) | 8235 (46.3) |
| Systemic lupus erythematosus | 536 (14.1) | 472 (13.9) | 574 (15.9) | 537 (17.2) | 620 (15.9) | 2739 (15.4) |
| Dermatologic conditions‡ | 793 (20.9) | 602 (17.8) | 643 (17.9) | 585 (18.6) | 633 (16.3) | 3256 (18.3) |
| Systemic autoimmune condition† | 438 (11.6) | 548 (16.2) | 541 (15.0) | 442 (14.2) | 651 (16.7) | 2620 (14.7) |
| Other | 357 (9.4) | 189 (5.6) | 137 (3.8) | 125 (4.0) | 139 (3.6) | 947 (5.3) |
BMI body mass index, CKD chronic kidney disease
*
Unless otherwise specified, results are reported as n (%)
‡
Includes alopecia, dermatitis, discoid lupus, granuloma annulare, lichen planus, subacute cutaneous lupus, psoriasis, and urticarial
†
Excludes systemic lupus erythematosus and rheumatoid arthritis