Table 2.
Hydroxychloroquine prescription dose in relation to dosing recommendations
| Characteristics | >6.5 mg/kg/day, actual body weight (prior recommendation) |
>5.0 mg/kg/day, ideal body weight (current recommendation) |
||||
|---|---|---|---|---|---|---|
| N (%) | Crude OR (95% CI) | Adjusted OR (95% CI) | N (%) | Crude OR (95% CI) | Adjusted OR (95% CI) | |
| Year of incident prescription | ||||||
| 2007–2008 | 1930 (53.2) | 1.00 (Reference) | 1.00 (Reference) | 1873 (49.4) | 1.00 (Reference) | 1.00 (Reference) |
| 2009–2010 | 1643 (50.6) | 0.90 (0.82–0.99) | 0.86 (0.77–0.95) | 1579 (46.6) | 0.89 (0.82–0.98) | 0.88 (0.79–0.98) |
| 2011–2012 | 1618 (46.7) | 0.77 (0.70–0.84) | 0.69 (0.62–0.76) | 1622 (45.1) | 0.84 (0.77–0.92) | 0.75 (0.67–0.83) |
| 2013–2014 | 777 (25.9) | 0.31 (0.28–0.34) | 0.24 (0.21–0.26) | 971 (31.1) | 0.46 (0.42–0.51) | 0.33 (0.30–0.38) |
| 2015–2016 | 1229 (32.7) | 0.43 (0.39–0.47) | 0.34 (0.30–0.37) | 1309 (33.6) | 0.52 (0.47–0.57) | 0.38 (0.34–0.43) |
| Sex | ||||||
| Female | 6971 (50.4) | 13.74 (11.96–15.79) | 17.91 (15.51–20.67) | 6352 (43.8) | 1.77 (1.64–1.92) | 2.20 (2.00–2.41) |
| Male | 226 (6.9) | 1.00 (Reference) | 1.00 (Reference) | 1002 (30.5) | 1.00 (Reference) | 1.00 (Reference) |
| Age | ||||||
| < 55 years | 4020 (43.6) | 1.00 (Reference) | 1.00 (Reference) | 3929 (41.3) | 1.00 (Reference) | 1.00 (Reference) |
| > 55 years | 3177 (40.3) | 0.87 (0.82–0.93) | 1.06 (0.99–1.14) | 3425 (41.4) | 1.00 (0.94–1.06) | 0.98 (0.91–1.05) |
| CKD stage | ||||||
| No CKD or CKD stage < 3 | 6926 (42.6) | 1.00 (Reference) | 1.00 (Reference) | 7058 (41.7) | 1.00 (Reference) | 1.00 (Reference) |
| CKD stage ≥ 3 | 271 (32.9) | 0.66 (0.57–0.77) | 0.80 (0.68–0.95) | 296 (34.2) | 0.73 (0.63–0.84) | 0.82 (0.69–0.97) |
| BMI | ||||||
| Underweight | 52 (21.9) | 0.50 (0.36–0.68) | 0.40 (0.29–0.55) | 146 (58.9) | 0.73 (0.57–0.95) | 0.67 (0.51–0.87) |
| Normal | 2053 (36.1) | 1.00 (Reference) | 1.00 (Reference) | 3916 (66.1) | 1.00 (Reference) | 1.00 (Reference) |
| Overweight | 2285 (41.9) | 1.28 (1.18–1.38) | 1.64 (1.51–1.79) | 2752 (48.5) | 0.48 (0.45–0.52) | 0.49 (0.45–0.53) |
| Obese | 2801 (49.1) | 1.71 (1.59–1.84) | 1.99 (1.83–2.16) | 526 (8.9) | 0.05 (0.05–0.06) | 0.04 (0.04–0.05) |
| Prescriber specialty | ||||||
| Rheumatologist | 4729 (40.0) | 1.00 (Reference) | 1.00 (Reference) | 4929 (40.1) | 1.00 (Reference) | 1.00 (Reference) |
| Primary care | 1395 (44.8) | 1.22 (1.13–1.32) | 1.15 (1.05–1.26) | 1334 (41.0) | 1.04 (0.96–1.12) | 0.97 (0.88–1.06) |
| Dermatologist | 747 (50.8) | 1.55 (1.39–1.72) | 2.03 (1.79–2.30) | 764 (50.4) | 1.52 (1.36–1.69) | 1.96 (1.72–2.23) |
| Other | 326 (47.5) | 1.36 (1.17–1.58) | 1.78 (1.49–2.13) | 327 (45.4) | 1.25 (1.07–1.45) | 1.46 (1.22–1.75) |
CKD chronic kidney disease, BMI body mass index