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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: J Mol Cell Cardiol. 2018 Oct 22;125:87–97. doi: 10.1016/j.yjmcc.2018.10.011

Fig 3.

Fig 3.

Angiotensin II (Ang II), phenylephrine (PE) or suramin induce GRK5 nuclear accumulation, but dantrolene (DAN) prevents this. (A), (C) Immunofluorescent images of GRK5 and nuclei (DAPI) in adult cardiomyocytes during control, 30min exposure to 10 μmol/L Ang II, Ang II+DAN, or 3hours exposure to suramin by protein delivery reagent. (B), (D) Summary of GRK5 translocation treatment with Ang II and PE with or without DAN, or suramin. Data are mean ± SE, n values on bars, *P<0.05 vs. control (Ctl), #P<0.05 vs. Ang II, ##P<0.05 vs. PE (one-way ANOVA followed by tukey-kramer’s post-test; Fig 3B, unpaired Student’s t-test; Fig 3D).