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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: J Mol Cell Cardiol. 2018 Oct 22;125:87–97. doi: 10.1016/j.yjmcc.2018.10.011

Fig 7.

Fig 7.

CaM, GRK5 and HDAC5 translocation of chronic pressure overload (TAC) mouse. (A), (C), (E) Immunofluorescent images of CaM and RyR2, GRK5, HDAC5 and nuclei (DAPI) in sham and TAC cardiomyocytes. After TAC (vs. sham), the binding affinity of CaM to RyR2 was lower and nuclear CaM was elevated along with GRK5. HDAC5 nuclear export increased in TAC model. (B), (D), (F) Summary of CaM, GRK5, HDAC5 translocation in 2, 8 weeks TAC model. Data are mean ± SE, n values on bars, *P<0.05 vs. sham (one-way ANOVA followed by dunnet’s post-test).