Table 3.

Distribution-based methods for determining MCID values for QOD-NS scores

	MCID Value Determinations
Measure	Cohens effect size (d) value*	1.0 Standard error of baseline measurement (SEM) value	0.5 baseline standard deviation value	Minimum detectable change (MDC) value	Mean
QOD-NS	2.6	3.1	6.5	8.6	5.2
Likelihood of achieving MCID for entire cohort	51%	43%	31%	26%	38%
Likelihood of achieving MCID in patients with abnormal QOD-NS (> 12.5) at baseline	70%	68%	58%	49%	63%

MCID, minimal clinically important difference; QOD-NS, Questionnaire for Olfactory Disorders, Negative Statements;