Skip to main content
. Author manuscript; available in PMC: 2019 Jul 14.
Published in final edited form as: Nat Immunol. 2019 Jan 14;20(2):141–151. doi: 10.1038/s41590-018-0293-x

Fig. 5. Elmo1 function regulates cell type-specific transcriptional programs.

Fig. 5.

a) Schematic for preparation of neutrophils and macrophages for RNA isolation and RNA-seq experiments.

b) Venn diagram of Elmo1-regulated transcripts in neutrophils and macrophages. Examples of shared and cell-type specific Elmo1-regulated transcripts are shown. Compared to Elmo1+/+ cells, those transcripts down-regulated or upregulated in Elmo1–/– cells are indicated in blue and red text, respectively.

c) Heatmap (each column represents an animal, n=4) and list of Elmo1-regulated neutrophil-specific transcripts with associations to human Rheumatoid Arthritis (RA). SNP – single nucleotide polymorphism; Tx – therapy.

d) Quantitative PCR validation of some neutrophil-specific arthritis-associated genes in c). Each symbol represents a mouse.