Table 1.
Country | Study | Years of study | Country child mortality rate,* per 1,000 live births | Child mortality rate* in control arm per 1,000 person-years | Number of communities | Azithromycin intervention | Control intervention |
---|---|---|---|---|---|---|---|
Ethiopia | TANA | 2006–2007 | 103.5 | 8.3 | 48 | Annual, biannual or quarterly mass azithromycin | Delayed mass azithromycin distribution |
Niger | PRET | 2010–2013 | 116.1 | 35.3 | 48 | Biannual mass azithromycin to children < 12 years | Annual mass azithromycin to the entire community |
Niger | MORDOR | 2015–2017 | 93.2 | 27.5 | 594 | Biannual mass azithromycin to children aged 1–59 months | Biannual placebo to children aged 1–59 months |
Malawi | MORDOR | 2015–2017 | 57.1 | 9.6 | 304 | Biannual mass azithromycin to children aged 1–59 months | Biannual placebo to children aged 1–59 months |
Tanzania | MORDOR | 2015–2017 | 57.8 | 5.5 | 614 | Biannual mass azithromycin to children aged 1–59 months | Biannual placebo to children aged 1–59 months |
MORDOR = Macrolide Oraux pour Réduire les Décès avec un Oeil sur la Résistance; PRET = Partnership for the Rapid Elimination of Trachoma; TANA = Trachoma Amelioration in Northern Amhara.
* Child mortality rates as estimated by United Nations International Children’s Emergency Fund (UNICEF) are expressed in number of deaths per 1,000 live births; mortality rates as estimated by the control arm in each trial are mortality rates per 1,000 person-years. Mortality rates per 1,000 person-years estimate the number of deaths per 1,000 persons per year, whereas mortality rates per 1,000 live births are the probability (per 1,000 live births) of a child dying before his or her fifth birthday (e.g., over a 5-year period).