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. 2019 Jan 15;27(3):531–541. doi: 10.1016/j.ymthe.2019.01.006

Figure 3.

Figure 3

Effects of circRNA.33186 on Proliferation and Apoptosis in IL-1β-Induced Chondrocytes

Chondrocytes were transfected with si-circRNA or si-NC, and then treated with 10 ng/mL IL-1β for 24 h. (A) The effect of circRNA.33186 on cell proliferation in vitro was determined by CCK8 assay. (B and D) Representative photomicrographs of EdU staining (B) and quantitative data showing the percentage of EdU-positive cells in different treatment groups (D). Blue: Hochest labeling of cell nuclei; Red: EdU labeling of nuclei of proliferative cells. Scale bars, 100 μm. (C and E) The effect of circRNA.33186 on cell apoptosis was measured by flow cytometric analysis (C), and the results of flow cytometric analysis are presented as percentages of positive mean values ± SD. *p < 0.01.