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. 2019 Jan 15;27(3):531–541. doi: 10.1016/j.ymthe.2019.01.006

Figure 4.

Figure 4

Silencing of circRNA.33186 In Vivo Alleviates DMM-Induced OA

(A) Schematic diagram illustrating the design of the OA therapeutic experiment targeting circRNA.33186. (B) qRT-PCR analysis of circRNA.33186 expression in knee articular cartilage from OA mice in different groups after surgery (n = 6). (C) The articular cartilage at the distal femur metaphysis was stained with H&E and toluidine blue. Scale bars, 200 μm. (D) Western blot analysis of Col2a1 and MMP13 expression in knee articular cartilage from OA mice in different groups. (E) Expression of Col2a1 and MMP13 were observed by immunohistochemistry staining in a DMM-induced OA mice model. Scale bars, 100 μm. *p < 0.01 compared with Sham group; #p < 0.01 compared with OA group.