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. 2019 Jan 15;27(3):531–541. doi: 10.1016/j.ymthe.2019.01.006

Figure 6.

Figure 6

MMP-13 Is a Direct Target of miR-127-5p

(A) Putative miR-127-5p binding site in the 3′ UTR of MMP-13 mRNA. (B) Sequence alignment of a putative miR-127-5p binding site within the 3′ UTR of MMP-13 mRNA shows a high level of sequence conservation and complementarity with miR-127-5p. (C) Interaction between miR-127-5p and MMP-13 was verified by luciferase report assay. (D and E) The effects of miR-127-5p on MMP-13 expression in chondrocytes were analyzed by qPCR (D) and western blot (E). *p < 0.01.