Table 5:
One-way, Two-way, and Three-way Comorbidity Combinations with the Highest Impact on Mortality
| Combination of comorbidities | Percent with Combination (Coverage) |
Percent died in-hospital (Confidence) |
Odds Ratio | Adjusted Odds Ratio | 95% Confidence Interval |
|---|---|---|---|---|---|
| One-way combination | |||||
| Coagulopathy | 8.3% | 17.2% | 4.35 | 3.74 | 3.41–4.11 |
| Fluid and Electrolyte Disorders | 44.1% | 9.4% | 3.89 | 2.89 | 2.66–3.14 |
| Liver Disease | 4.7% | 7.2% | 1.32 | 1.89 | 1.61–2.22 |
| Weight Loss | 14.8% | 11.9% | 2.86 | 1.84 | 1.70–2.01 |
| Peripheral Vascular Disorders | 11.7% | 10.5% | 2.24 | 1.82 | 1.66–2.00 |
| Paralysis | 1.9% | 10.3% | 1.97 | 1.78 | 1.44–2.19 |
| Congestive Heart Failure | 15.9% | 9.4% | 2.03 | 1.74 | 1.59–1.90 |
| Arrhythmias | 33.2% | 8.4% | 2.09 | 1.73 | 1.60–1.86 |
| Pulmonary Circulation Disorders | 4.4% | 9.8% | 1.89 | 1.65 | 1.43–1.91 |
| Renal Failure | 18.5% | 8.1% | 1.66 | 1.53 | 1.40–1.67 |
| Two-way combination | |||||
| Coagulopathy & Fluid and Electrolyte Disorders | 5.3% | 22.4% | 5.91 | 4.65 | 4.20–5.15 |
| Coagulopathy & Peripheral Vascular Disorders | 1.4% | 24.5% | 5.76 | 4.21 | 3.52–5.04 |
| Liver Disease & Weight Loss | 0.7% | 18.1% | 3.77 | 3.71 | 2.84–4.85 |
| Coagulopathy & Arrhythmias | 3.7% | 19.1% | 4.40 | 3.64 | 3.22–4.12 |
| Coagulopathy & Chronic Pulmonary Disease | 1.9% | 19.0% | 4.16 | 3.58 | 3.03–4.23 |
| Coagulopathy & Weight Loss | 2.2% | 21.4% | 4.89 | 3.37 | 2.90–3.92 |
| Fluid and Electrolyte Disorders & Liver Disease | 2.1% | 13.1% | 2.61 | 3.09 | 2.56–3.72 |
| Fluid and Electrolyte Disorders & Peripheral Vascular Disorders |
6.0% | 16.0% | 3.67 | 2.61 | 2.35–2.90 |
| Fluid and Electrolyte Disorders & Paralysis | 1.1% | 14.5% | 2.91 | 2.43 | 1.90–3.10 |
| Fluid and Electrolyte Disorders & Arrhythmias | 17.1% | 12.2% | 3.13 | 2.37 | 2.19–2.56 |
| Three-way combination | |||||
| Coagulopathy & Fluid and Electrolyte Disorders & Peripheral Vascular Disorders |
1.0% | 30.2% | 7.62 | 5.10 | 4.17–6.24 |
| Coagulopathy & Fluid and Electrolyte Disorders & Chronic Pulmonary Disease |
1.3% | 25.0% | 5.89 | 4.83 | 4.00–5.82 |
| Fluid and Electrolyte Disorders & Liver Disease & Weight Loss |
0.5% | 21.6% | 4.71 | 4.43 | 3.30–5.97 |
| Coagulopathy & Chronic Pulmonary Disease & Arrhythmias |
1.0% | 21.2% | 4.65 | 3.89 | 3.10–4.87 |
| Coagulopathy & Congestive Heart Failure & Chronic Pulmonary Disease |
0.7% | 21.2% | 4.61 | 3.81 | 2.91–5.00 |
| Coagulopathy & Congestive Heart Failure & Weight Loss |
0.6% | 24.1% | 5.43 | 3.61 | 2.73–4.78 |
| Fluid and Electrolyte Disorders & Liver Disease & Arrhythmias |
0.7% | 15.8% | 3.20 | 3.49 | 2.60–4.67 |
| Fluid and Electrolyte Disorders & Peripheral Vascular Disorders & Arrhythmias |
2.7% | 18.3% | 4.05 | 2.88 | 2.49–3.31 |
| Fluid and Electrolyte Disorders & Peripheral Vascular Disorders & Renal Failure |
1.9% | 18.0% | 3.87 | 2.87 | 2.42–3.40 |
| Fluid and Electrolyte Disorders & Pulmonary Circulation Disorders & Renal Failure |
0.8% | 15.9% | 3.24 | 2.77 | 2.13–3.62 |
Coverage = percentage of population with that combination
Confidence = percentage of population that have the outcome (i.e. died in-hospital), among those with the combination
Adjusted Odds Ratio calculated with multivariable logistic regression, adjusted for all variables in Table 1. The p-value from the Wald test for all odds ratios and adjusted odds ratios presented in the table is p<0.001.