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. Author manuscript; available in PMC: 2020 Mar 5.
Published in final edited form as: Cell Metab. 2019 Jan 24;29(3):736–744.e7. doi: 10.1016/j.cmet.2018.12.022

Scheme 2.

Scheme 2.

Synthesis of Oxyphor 2P. Reagents and conditions: (a) HBTU, DIPEA, DMF, r.t., 48–72 h (90–95%); (b) Pd(PPh3)4, morpholine, DMF, r.t., 48 h (90–95%); (c) NH2-PEG (Av. MW~1000), HBTU, DIPEA, DMF, r.t., 120–168 h (80–90%).