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. Author manuscript; available in PMC: 2020 Mar 30.
Published in final edited form as: Arch Biochem Biophys. 2019 Jan 26;664:40–50. doi: 10.1016/j.abb.2019.01.028

Figure 1.

Figure 1.

(A) Role of PvdF in pyoverdin biosynthesis. PvdA and PvdF derivatize ornithine to generate the precursor N5-formyl-N5-hydroxyornithine (fOHOrn). This molecule is subsequently incorporated into pyoverdin by nonribosomal peptide synthetases PvdF catalyzes formyl group transfer from N10-formyltetrahydrofolate (N10-fTHF) to N5 of N5-hydroxyornithine. (B) Chemical representation of N10-formyl-THF (right) and cofactor analogue fDDF (left). The ring altered between the cofactor and the analogue is highlighted in blue.