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. Author manuscript; available in PMC: 2020 Mar 6.
Published in final edited form as: J Am Chem Soc. 2019 Feb 20;141(9):3901–3909. doi: 10.1021/jacs.8b11838

Figure 1. Design of a CuH-catalyzed indole alkylation reaction using electrophilic indole reagents.

Figure 1.

a) Representative biologically active N- and C3-substituted α-chiral indoles. b) Regioselectivity in conventional enantioselective indole alkylation reactions. c) Proposed mechanistic pathway of enantioselective alkylation of electrophilic indoles. d) Ligand-controlled regiodivergent alkylation of electrophilic indoles.