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. Author manuscript; available in PMC: 2019 Aug 18.
Published in final edited form as: Nat Struct Mol Biol. 2019 Feb 18;26(3):175–184. doi: 10.1038/s41594-019-0189-y

Figure 1. Dynamic 3D chromatin organization in late spermatogenesis.

Figure 1.

a, Schematic of stages of late spermatogenesis analyzed in this study. PS: pachytene spermatocyte; RS: round spermatid. b, Heatmaps showing normalized Hi-C interaction frequencies (128-kb bins, chromosome 2) in PS, RS, sperm, and embryonic stem cells (ESC). c, d, Hi-C intrachromosomal interaction frequency probabilities P stratified by genomic distance s for each cell type shown in the panels (100-kb bins, all chromosomes). MII oocyte: metaphase meiosis II oocyte; HFF1-mitosis: synchronized prometaphase mitosis human foreskin fibroblasts. The blue shadow indicates intrachromosomal interactions up to 3 Mb, and the grey shadow indicates intrachromosomal interactions at and beyond 3 Mb. Scaling coefficients are shown in the panels. e, log2 ratio comparisons of the Hi-C interaction frequencies (128-kb bins, chromosome 2) for successive cell types. Details and metrics for Hi-C datasets are presented in Supplementary Dataset 2.