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. Author manuscript; available in PMC: 2019 Aug 18.
Published in final edited form as: Nat Struct Mol Biol. 2019 Feb 18;26(3):175–184. doi: 10.1038/s41594-019-0189-y

Figure 6. Chromosome X lacks higher-order structure during meiotic and postmeitoic silencing.

Figure 6.

a, Heatmaps showing normalized Hi-C interaction frequencies (128-kb bins, chromosome X) in pachytene spermatocytes (PS), round spermatids (RS), sperm, and embryonic stem cells (ESC). b, log2 ratio comparisons between the Hi-C interaction frequencies for successive cell types (128-kb bins, chromosome X). c, Pearson’s correlation for Hi-C interaction frequencies (128-kb bins, chromosome X), which captures genomic compartmentalization patterns in all cell types. d, Eigenvector 1 (EV1) from principle component analysis, RNA-seq data, and ChIP-seq data for H3K27ac, H3K4me3, and H3K27me3 to classify genomic compartments as active (A) and repressed (B) in all cell types (128-kb bins, chromosome X). e, X intrachromosomal interactions determined by the measurement of genomic compartment strength (Methods). First eigenvectors from principle component analysis are presented in Supplementary Dataset 3.