Figure 4.

Applications of Noninvasive Monitoring During the Course of Cancer Evolution. Cancers share a common theme in developing intratumoral heterogeneity during their natural history. The presence of subclones (represented by different colors) confers significant implications in the response to treatment and may be difficult to capture through standard biopsies. Imaging and blood biomarkers during disease monitoring offer a potential technological solution for detecting the presence of intratumoral heterogeneity through space and time and thereby, perhaps, a direct change in therapeutic strategies.