Figure 3.

KM survival probability analysis results are summarized as stair-step graphs for conventional histogram metrics of total T1Gd tumor volume in (A–C), mean ADC in (D–F), and low ADC (<1.25 × 10⁻³ mm²/s) histogram volume in (G–I). Magenta and cyan KM trends correspond to the tumor characteristics, respectively, above and below median response threshold for the studied ADC histogram metrics. The color flip from cyan to magenta for responder KM trends (with higher probability of survival) between mean ADC (D–F) and volume-based metrics (A–C, G–I) reflects negative change in tumor volume versus positive change in ADC metrics. Time-dependent distance between KM curves reports on predictive power of the studied histogram metrics. Vertical tick-marks along KM trends indicate individual patients whose survival times have been censored. Dashed vertical line corresponds to the minimal survival time included into the corresponding KM CDF probability analysis (excluding survival for the late censored patients).