Table 2.
Group Differences on the Probabilistic Category Learning Task in Whole-Brain Analyses
Region | Volume of Voxels (mm3) | Peak Activity MNI Coordinates | Maximum Z-Statistic | Exact P-Value | ||
---|---|---|---|---|---|---|
x | y | z | ||||
Regions significantly more active for the comparison group than psychosis risk | ||||||
Right caudate | 197 | 12 | 14 | 8 | 3.78 | 0.0001 |
Right putamen | 16 | 14 | −6 | 3.97 | 4.7e-05 | |
Right hippocampus | 16 | −12 | −18 | 3.06 | 0.0012 | |
Left thalamus | −4 | −18 | 6 | 4.11 | 2.7e-05 | |
Right anterior cingulate cortex | 17855 | 10 | 44 | 8 | 4.48 | 5.7e-06 |
Left inferior frontal gyrus | −46 | 38 | 8 | 6.59 | 1.3e-10 | |
Right middle frontal gyrus | 48 | 34 | 24 | 10.5 | 6.0e-22 | |
Left superior frontal gyrus | −22 | −2 | 58 | 4.97 | 6.4e-07 | |
Right thalamus | 8 | −22 | 6 | 4.49 | 5.6e-06 | |
Right superior parietal lobe | 2 | −70 | 38 | 6.22 | 1.1e-09 | |
Regions significantly more active for psychosis risk than the comparison group | ||||||
Right inferior temporal gyrus | 196 | 66 | −42 | −16 | 6.84 | 3.1e-11 |
Right anterior intraparietal sulcus | 191 | 26 | −50 | 38 | 6.39 | 4.2e-10 |
Right visual cortex (V4) | 757 | 32 | −78 | −18 | 9.72 | 2.1e-19 |
Left visual cortex (V4) | 316 | −30 | −86 | −14 | 5.78 | 1.1e-08 |
Note: Analyses were also run with a cluster threshold of Z = 4.30, P > .01 FWE-corrected. For the analyses of regions significantly more active for the comparison group than psychosis risk, the results were largely similar, except that the hippocampus was no longer significantly activated. For the analyses of regions significantly more active for psychosis risk than the comparison group, there were no clusters of significant activation.