Table 3.

Cross-sectional Associations Between Metabolic Markers and PEs at Age 18

Predictor	OR (95% CI) for Psychotic Outcomes
	Unadjusted Model			Adjusted for Sex, Ethnicity, Social Class, BMIa and Smoking, Gestational Age, Birthweight
Definite PEs	n	OR (95% CI)	P	OR (95% CI)	P
IR	2627	2.41(1.50–4.40)	<.001*	2.32 (1.37–3.97)	<.001*
HOMA2	2627	1.34 (1.17–3.18)	.019*	1.19 (1.01–1.43)	.034*
HOMA2 × HOMA2	2627	1.23 (1.06–3.09)	.008*	1.08 (1.01–1.15)	.021*
FPG	2627	0.89 (0.72–6.56)	.670	0.96 (0.13–7.28)	.966
FPG × FPG	2627	0.92 (0.82–1.06)	.762	0.99 (0.82–1.19)	.904
Fasting insulin	2627	1.36 (1.02–1.78)	.019*	1.23 (1.03–1.47)	.023*
Fasting insulin × fasting insulin	2627	1.07 (0.99–1.78)	.201	1.02 (0.95–1.10)	.526
Metabolic syndrome	2627	1.62 (0.77–3.39)	.204	1.68 (0.71–3.97)	.244

Note: BMI, body mass index; HOMA₂, Homeostasis Model Assessment for Insulin Resistance; IR, insulin resistance; PEs, psychotic experiences. IR as categorical variable defined as HOMA₂ >1.79. HOMA₂, FPG, and Fasting Insulin presented as continuous variables.

^aNot adjusted for in Metabolic Syndrome analysis.

*P < .05.