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. 2018 Jan 13;22(3):247–259. doi: 10.1093/ijnp/pyy101

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© The Author(s) 2018. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Rapastinel produces an acute and sustained antidepressant-like effect. (A) Rapastinel and S-ketamine produce dose-dependent antidepressant-like responses in the rat forced swim test (FST; n = 6 rats per group, *P < .05, **P < .01, ***P < .001 vs vehicle, 1-way ANOVA, Bonferroni’s multiple comparison test). (B) Dose-dependent increase in extracellular levels of rapastinel in medial prefrontal cortex (mPFC) of awake rats (n = 3 rats). Dashed line indicates lower limit of quantitation. Data are mean ± SEM.