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. 2019 Feb 28;10:156. doi: 10.3389/fphar.2019.00156

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Copyright © 2019 Huynh, Penney, Caswell and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protegrin treatments ameliorate weight loss and disease activity index (DAI) in DSS-induced colitis in mice. By day 8, mice administered DSS and treated with protegrin [pro-form (ProPG) Cathelin or mature PG-1] have significantly (^∗P < 0.05) significantly less weight loss (A) and improved total DAI scores (B) compared to the mice administered DSS but given PBS instead of protegrin (PBS + DSS). PBS: mice not administered DSS, treated with PBS. Higher DAI score indicates more severe disease signs. Significance was determined using a one-ray ANOVA with a post hoc Tukey test. Data represent the mean ± SEM of 12 mice per treatment.