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. 2019 Feb 28;10:156. doi: 10.3389/fphar.2019.00156

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Copyright © 2019 Huynh, Penney, Caswell and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protegrin improves colonic histomorphology in DSS-induced colitis in mice. (A) DSS-induced mucosal crypt loss (arrow), erosion and inflammation. Protegrin-treated groups (ProPG and mPG-1) have less mucosal erosion (^∗) and submucosal inflammation (arrow) when compared to the DSS-only treatment group (PBS + DSS); (B) pathologic score. Surface epithelial loss, inflammatory cell infiltration into the mucosa, and crypt destruction were scored (0 for no change; 1 for localized and mild, 2 for localized and moderate; 3 for extensive and moderate; 4 for extensive and severe). The pathologic score is the sum of the scores for these three parameters. (C) Goblet cell count (goblet cells per crypt). Data represent the mean ± SEM of three mice per treatment. Different letter superscripts denote significant difference between groups (P < 0.05) calculated using a one-way ANOVA with a post hoc Tukey test.