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. 2019 Feb 28;9:37. doi: 10.3389/fcimb.2019.00037

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Copyright © 2019 Liu, Shukla, Vera-González, Tharmalingam, Mylonakis, Fuchs and Shukla.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antibiofilm efficacy of coated catheters. (A) Bioluminescence (radiance) of MRSA USA300 Lac::Lux examined using IVIS. Catheters were either uncoated or coated with auranofin only (at a 3 mg/mL coating concentration), PU only, PU+vancomycin, or PU+auranofin at 2 different drug coating concentrations (3 and 10 mg/mL). Samples were exposed to USA300, rinsed, and potentially attached biofilms were allowed to mature over 2 days prior to measurement. (B) The colony forming units of USA300 recovered from the different catheter groups imaged in (A). Data are shown as mean ± standard deviation where ***p < 0.001 indicates significance between CFU for the samples evaluated using one-way ANOVA (n = 3).