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. 2019 Feb 28;10:147. doi: 10.3389/fphar.2019.00147

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Copyright © 2019 Ghareghani, Scavo, Jand, Farhadi, Sadeghi, Ghanbari, Mondello, Arnoult, Gharaghani and Zibara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of melatonin on brain lactate and NAA. Levels of brain (A) lactate and (B) N-acetylaspartate (NAA) were measured by HPLC at day 30 post-first immunization. Only pharmacological doses (High Mel) of melatonin significantly increased brain levels of lactate and NAA, compared to PBS treated EAE mice. Data are expressed as μmol/g brain. Values are expressed as the Mean ± SEM. Each group included 8 mice (n = 8). Statistical analysis was performed by two-way analysis of variance (ANOVA) followed by Tukey’s test. Significance is indicated by ^∗∗∗p < 0.001 vs. control-PBS, ^#p < 0.05 vs. EAE-PBS, and & vs. EAE-Low melatonin.