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. 2019 Feb 28;10:147. doi: 10.3389/fphar.2019.00147

FIGURE 7.

FIGURE 7

The effects of melatonin on PDC activities in brain homogenates. The change in the activity of PDC enzyme was measured either at the (A) “active” or (B) “total” forms of PDC. Melatonin significantly decreased the activities of both PDC forms, in comparison to PBS treated EAE mice. Values are expressed as the Mean ± SEM. Each group included 8 mice (n = 8). Statistical analysis was performed by one-way analysis of variance (ANOVA) followed by Tukey’s test. Significance is indicated by p < 0.05, ∗∗p < 0.01, and ∗∗∗∗p < 0.0001.