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. 2019 Feb 28;10:167. doi: 10.3389/fphys.2019.00167

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Copyright © 2019 Wang, Tao, Wang, Yang, Ning, Xin, Xu, Cai, Zhang, Yu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed mechanism of regulation of BK channels by mTORC2 in podocyte. mTOR protein complexes contains mTORC1 and mTORC2 in podocytes. mTORC2 phosphorylates and activates its substrates, Akt and SGK1. mTORC2 modulates BK channels in podocytes via two different pathways. One way is mTORC2 mediates BK channel activity by influencing the surface expression of BK channels through Akt. The other is mTORC2 regulation of BK protein expression through SGK1 in podocytes. However, mTORC1 did not regulate BK in podocytes.