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. 2019 Mar 6;9:3620. doi: 10.1038/s41598-019-39995-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Visual outcome of eyes with neovascular age-related macular degeneration treated with intravitreal aflibercept injections. The solid line in the top panel shows the overall result of eyes, which completed the four-year follow-up. Visual gain in the first year was gradually lost in the following years, but the vision remained above the baseline level even at year four. A dotted line shows the data of all patients including those who dropped out. Missing data were imputed with a last observation carried forward policy. The visual course in the cohort was essentially similar despite the difference of baseline visual acuity, indicating the data of survivors can be approximated as a representation of the overall cohort. The bottom graph shows the percentage of patients who gained or lost more than three lines of vision. All the patients gained or maintained vision in the first year. Although some patients lost vision in the following years, 94.5% maintained their vision even at year four.