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. 2019 Mar 6;9:3710. doi: 10.1038/s41598-019-40124-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Flow cytometry for integrin β7 and CD62L in IBS patients and HV. (A) Flow cytometry revealed a significant increase in the % of CD4+ T-cells expressing the gut homing marker, integrin β7, in patients with IBS (38.3% [34.8–43.1], n = 12) when compared to HV (30.2% [22.5–35.6], n = 12; p = 0.023 vs. IBS). A significant increase in the % of CD4+ T-cells expressing the lymph node homing marker, CD62L was also seen in IBS (B) (IBS: 85.2% [83.3–88.9], n = 12; HV: 80.1% [73.5–84.4], n = 12; p = 0.026), as well as in the % of CD4+ T-cells co-expressing CD62L and integrin β7 (C) (IBS: 35.6% [30.2–42.2], n = 12; HV: 27.3% [17.4–32.5], n = 12; p = 0.040, when compared to HV).