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. 2019 Mar 6;5:74. doi: 10.1038/s41420-019-0145-y

Fig. 6. FUT1-modified glycans positively regulate cell migration through Globo H.

Fig. 6

a, Immunohistochemistry staining of Globo H expression in excised T47D or MCF7 tumor xenografts expressing shLuc, shFUT1, or shFUT2 and flow cytometry analysis of Globo H in T47D, MCF7, and MDA-MB-231 cells with indicated conditions. Scale bars, 50 μm. b, Flow analysis of Globo H expression in T47D or MCF7 cells expressing shLuc, shFUT1, or shFUT2 with or without Globo H-ceramide. c, Cell adhesion ability of T47D cells expressing shFUT2 or shLuc to polystyrene in the presence or absence of Globo H-ceramide were measured by RT-CES system up to 2 h. d, Cell migration toward serum of MCF7 cells expressing shLuc or shFUT1 in the presence or absence of Globo H-ceramide was determined by a RT-CIM system