Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 6;10:1087. doi: 10.1038/s41467-019-09001-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Illustration of the multiple radical-sensitive approach for dynamic profiling of pathophysiology implications in vivo. a Design of near-infrared (NIR) light-mediated upconversion nanoprobe by incorporating reactive oxygen and nitrogen species (ROS)-responsive HCy5 and reactive nitrogen species (RNS)-responsive Cy7 onto upconversion nanocrystal (UCN) surface. Upon radical stimulation, HCy5 and Cy7 underwent the structural regeneration and degradation, respectively, leading to ratiometric upconverted luminescence (UCL) and optoacoustic (OA) signal variations in NIR spectral region. b Dynamic profiling of pathophysiological implications to explore the underlying radical-induced inflammations by tailoring multispectral optoacoustic tomography (MSOT) with optical properties of UCNs in live mice