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. 2019 Mar 6;9:3680. doi: 10.1038/s41598-019-39216-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of t_1/2 of aggregation for different variants [Aβ40 wild-type, D1K, D1N, D7N, H13R, H14R, H6R, E3Q, E3K, K28Q and N27D] vs. concentration. Log-log plots of faster fibril forming mutants (D1K, D1N, H13R, H14R and D7N) lie below the Aβ40 wild-type curve while the slower fibril forming mutant (E3K, K28Q and N27D) show its curve above the wild-type. H6R and E3Q almost merge with the Aβ40 wild-type. Data points between the arrows represent the half time points of concentrations 32 µM (E3K – 20 µM) to lowest possible. D23N is not included as we have half times available only for three different concentrations.