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. 2019 Mar 6;9:109. doi: 10.1038/s41398-019-0445-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Mean water consumption in mL (±SEM) during home-cage water accesses before (black circles) and after (white circles) Free Water (FW) sessions. ^#Difference between before and after (p < 0.0001). *Different from the first FW session (p < 0.001). b Percent of volume self-delivered (±SEM) across deprivation (baseline) and FW sessions. ^#Difference between baseline and FW sessions (p < 0.0001). c Mean percent of cocaine and water choices (±SEM) as a function of FW sessions. The horizontal dashed line at 50% represents the indifference level. *Different from the indifference level (p < 0.05, t-test). d Mean percent of suboptimal water choices not followed by consumption (±SEM), as a function of FW sessions. *Different from first FW session (p < 0.01). e Mean water sampling latency (±SEM) in the first and second trials of FW sessions (gray and white circles) and during baseline sessions (black circles). ^#Difference between 1st and 2nd sampling trials of FW sessions (p < 0.05). *Different from baseline sessions (p < 0.05). f Mean choice latency (±SEM) across FW and baseline sessions. ^#Difference between Free Water and baseline sessions (p < 0.0001)